Abstract | AIMS: METHODS AND RESULTS: The antiviral activity of tested compounds was evaluated against polio type 1, ECHO 9, Coxsackie B1, adeno type 2, herpes simplex (HSV) type 1 and 2 viruses by 50% plaque reduction assay. The anti-influenza virus assay was based on the inhibition of the virus-induced cytopathogenicity. Results obtained from our screening demonstrated that the TTO and some of its components (the terpinen-4-ol, the terpinolene, the alpha-terpineol) have an inhibitory effect on influenza A/PR/8 virus subtype H1N1 replication at doses below the cytotoxic dose. The ID(50) value of the TTO was found to be 0.0006% (v/v) and was much lower than its CD(50) (0.025% v/v). All the compounds were ineffective against polio 1, adeno 2, ECHO 9, Coxsackie B1, HSV-1 and HSV-2. None of the tested compounds showed virucidal activity. Only a slight virucidal effect was observed for TTO (0.125% v/v) against HSV-1 and HSV-2. CONCLUSIONS: SIGNIFICANCE AND IMPACT OF THE STUDY: TTO should be a promising drug in the treatment of influenza virus infection.
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Authors | A Garozzo, R Timpanaro, B Bisignano, P M Furneri, G Bisignano, A Castro |
Journal | Letters in applied microbiology
(Lett Appl Microbiol)
Vol. 49
Issue 6
Pg. 806-8
(Dec 2009)
ISSN: 1472-765X [Electronic] England |
PMID | 19843207
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Insecticides
- Monoterpenes
- Tea Tree Oil
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Topics |
- Antiviral Agents
(pharmacology)
- Drug Resistance, Viral
(drug effects)
- Enterovirus
(drug effects)
- Influenza A Virus, H1N1 Subtype
(drug effects)
- Inhibitory Concentration 50
- Insecticides
(pharmacology)
- Microbial Sensitivity Tests
- Monoterpenes
(pharmacology)
- Simplexvirus
(drug effects)
- Tea Tree Oil
(pharmacology)
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