Massive ascites after living donor liver transplantation with a right lobe graft larger than 0.8% of the recipient's body weight.

Abstract

BACKGROUND:

There are only limited data on post-transplant ascites unrelated to small-sized grafts in living donor liver transplantation (LDLT).

METHODS:

The subjects were 59 adult patients who had received right lobe LDLT with a graft weight-to-recipient weight ratio (GRWR)>0.8%. Patients were divided into either Group 1 (n=14, massive ascites, defined as the production of ascitic fluid>1000 mL/d that lasted longer than 14 d after LDLT) or Group 2 (n=45, no development of massive ascites). Patients were followed for a median period of 3.0 yr (range, 0.5-7.5 yr).

RESULTS:

Group 1 had both higher Model for End-Stage Liver Disease score and Child-Pugh score than Group 2. Portal venous flow volume just after reperfusion was significantly greater in Group 1 than Group 2 (307.8±268.8 vs. 176.2±75.0 mL/min/100 g graft weight, respectively; p<0.05). Post-transplant infectious complications including ascites infection developed more frequently within the first post-transplant month in Group 1. Massive ascites was significantly associated with early graft loss (p<0.05).

CONCLUSION:

Post-transplant massive ascites associated with portal over-perfusion into the graft liver can develop in patients with a GRWR over 0.8%. Recipients with post-transplant massive ascites require careful management to prevent infection.

• Authors: Yasumasa Shirouzu, Yuki Ohya, Hiroko Suda, Katsuhiro Asonuma, Yukihiro Inomata
• Journal: Clinical transplantation (Clin Transplant) 2010 Jul-Aug Vol. 24 Issue 4 Pg. 520-7 ISSN: 1399-0012 [Electronic] Denmark
• PMID: 19843111 (Publication Type: Journal Article)
• Copyright: © 2009 John Wiley & Sons A/S.

Topics

• Adolescent
• Adult
• Aged
• Ascites (etiology, pathology)
• Body Weight
• Female
• Graft Survival
• Humans
• Liver (anatomy & histology, surgery)
• Liver Failure (therapy)
• Liver Transplantation (adverse effects)
• Living Donors
• Male
• Middle Aged
• Organ Size
• Postoperative Complications
• Retrospective Studies
• Treatment Outcome
• Young Adult