Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia.

Abstract

(+/-)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of (+/-)-laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that (+/-)-laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.

• Authors: Martin J Lear, Oliver Simon, Timothy L Foley, Michael D Burkart, Thomas J Baiga, Joseph P Noel, Antonio G DiPasquale, Arnold L Rheingold, James J La Clair
• Journal: Journal of natural products (J Nat Prod) Vol. 72 Issue 11 Pg. 1980-7 (Nov 2009) ISSN: 1520-6025 [Electronic] United States
• PMID: 19842686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzofurans
• laetirobin

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Benzofurans (chemistry, isolation & purification, pharmacology)
• Cell Division (drug effects)
• Coriolaceae (chemistry)
• Crystallography, X-Ray
• Drug Screening Assays, Antitumor
• Fruiting Bodies, Fungal (chemistry)
• Mitosis (drug effects)
• Molecular Conformation
• Nuclear Magnetic Resonance, Biomolecular
• Robinia (microbiology)
• Stereoisomerism