Abstract |
To assess the potency, efficacy and toxicity of abacavir/lamivudine (ABC/3TC) versus tenfovir/emcitrabine (TDF/ FTC) with efavirenz (EFV) in naive patients with HIV infection a prospective observational study was carried out to evaluate immunovirological parameters every three months and metabolic parameters every six months. In all, 21 patients were enrolled (10 on ABC/3TC and 11 on TDF/ FTC). Fisher's test revealed no statistically significant difference between the two arms in terms of immunological recovery and control of viral replication. For metabolic parameters at week 48 no statistically significant differences were noted between the two arms. The two ABC/3TC and TDF/ FTC backbones showed the same potency; ABC had a more negative impact on metabolic parameters without statistical power.
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Authors | Martina Gottardi, Massimiliano Lanzafame, Emanuela Lattuada, Fabio Soldani, Fabio Boccafoglio, Ercole Concia |
Journal | Le infezioni in medicina
(Infez Med)
Vol. 17
Issue 3
Pg. 151-8
(Sep 2009)
ISSN: 1124-9390 [Print] Italy |
Vernacular Title | Efficacia e sicurezza dei regimi TAM-sparing in pazienti naïve con infezione da HIV. |
PMID | 19838086
(Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Alkynes
- Anti-HIV Agents
- Benzoxazines
- Cyclopropanes
- Dideoxynucleosides
- Organophosphonates
- Deoxycytidine
- Lamivudine
- Tenofovir
- Emtricitabine
- Adenine
- efavirenz
- Thymidine
- abacavir
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Topics |
- Adenine
(analogs & derivatives)
- Adult
- Alkynes
- Anti-HIV Agents
(administration & dosage, adverse effects, therapeutic use)
- Benzoxazines
(pharmacology, therapeutic use)
- CD4 Lymphocyte Count
- Cyclopropanes
- Deoxycytidine
(analogs & derivatives)
- Dideoxynucleosides
- Drug Therapy, Combination
- Emtricitabine
- Female
- HIV Infections
(blood, drug therapy)
- HIV-1
- Humans
- Hyperinsulinism
(chemically induced)
- Hyperlipidemias
(chemically induced)
- Lamivudine
- Male
- Middle Aged
- Mutation
- Organophosphonates
- Prospective Studies
- Tenofovir
- Thymidine
(metabolism)
- Treatment Outcome
- Young Adult
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