[A case of recurrent gastric cancer during adjuvant chemotherapy with S-1, treated by S-1 combination chemotherapy].

Abstract

A 59-year-old man was admitted to our hospital for the treatment of gastric cancer with synchronous and multiple metastatic liver tumors. After total gastrectomy in February 2005, partial resection of the posterior segment of the liver was carried out in the next month. Pathological study of both the resected specimens showed moderately differentiated adenocarcinoma. The postoperative treatment with S-1 was initiated without any evidence of recurrence. However, CT scans showed recurrent multiple liver tumors after 4 courses of treatment with S-1. Subsequently, a combination chemotherapy of S-1 (80 mg/m(2) over day 1-14 with a 2-week rest) and paclitaxel (PTX) (120 mg/m(2), day 1 and 15) was applied. After 3 courses, CT scans showed reduced liver metastases, judged as a partial response(PR)on Response Evaluation Criteria in Solid Tumors (RECIST). However, metastatic liver tumors showed progressive disease (PD) after 7 courses of treatment. The treatment was changed to combination chemotherapy with S-1 (80 mg/m(2) over day 1-21 with a 2-week rest) and CPT-11 (80 mg/m(2) day, day 1 and 15) for 6 courses, but the legions showed PD. He was then treated with combined chemotherapy with S-1 (70 mg/m(2) over day 1-14 with a 1-week rest)and cisplatin (CDDP) (10 mg/m(2), day 1 and 8). However, his condition became worse and he was treated at the palliative care unit. There were no adverse effects greater than grade 4 throughout the treatment period, and his treatment was continued as an outpatient for more than two years. This case suggests that after failure of S-1 therapy, S-1 combination chemotherapy might be an effective treatment for recurrent gastric cancer.

• Authors: Nobuhiro Shibata, Tada-Aki Eto, Takashi Asada, Tsuyoshi Takaya, Shunichi Tanaka, Toshio Shimayama, Shinichi Imada, Shigemi Futami, Hideki Hidaka, Kazuo Chijiiwa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 10 Pg. 1745-8 (Oct 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19838040 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Paclitaxel
• Cisplatin
• Camptothecin

Topics

• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives, therapeutic use)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage, therapeutic use)
• Drug Combinations
• Fatal Outcome
• Gastrectomy
• Humans
• Irinotecan
• Liver Neoplasms (diagnostic imaging, drug therapy, secondary)
• Male
• Middle Aged
• Oxonic Acid (administration & dosage, therapeutic use)
• Paclitaxel (administration & dosage, therapeutic use)
• Recurrence
• Stomach Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed