Supratentorial, extraventricular choroid plexus carcinoma in an adult: case report.

Abstract

OBJECTIVE:

Choroid plexus carcinoma (CPCa) is an uncommon tumor rarely occurring in patients older than 2 years of age. The case reported herein represents the first documented example of a primary supratentorial, extraventricular CPCa in an adult. The scant literature regarding this topic is reviewed.

CLINICAL PRESENTATION:

A 68-year-old woman presented with transient expressive aphasia. Magnetic resonance imaging demonstrated an avidly enhancing, left temporal, extra-axial mass with associated parenchymal cysts.

INTERVENTION:

The tumor was gross-totally removed via a frontotemporal craniotomy. A diagnosis of CPCa was made on histological, immunohistochemical, and ultrastructural grounds. Postoperatively, the patient was treated by local radiotherapy and temozolomide. A magnetic resonance imaging scan 44 months after surgery showed no evidence of residual or recurrent tumor.

CONCLUSION:

CPCa infrequently affects adults. Only rarely does it present as a supratentorial, extraventricular mass. Resection is the mainstay of therapy. Adjuvant radiation and chemotherapy are rational treatment options.

• Authors: Alan P Lozier, Yamil M Arbaje, Bernd W Scheithauer
• Journal: Neurosurgery (Neurosurgery) Vol. 65 Issue 4 Pg. E816-7 (Oct 2009) ISSN: 1524-4040 [Electronic] United States
• PMID: 19834361 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Dacarbazine
• Temozolomide

Topics

• Aged
• Antineoplastic Agents, Alkylating (therapeutic use)
• Brain (pathology, physiopathology, surgery)
• Carcinoma (pathology, physiopathology, surgery)
• Choroid Plexus (pathology, physiopathology, surgery)
• Choroid Plexus Neoplasms (pathology, physiopathology, surgery)
• Craniotomy
• Dacarbazine (analogs & derivatives, therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Lateral Ventricles (pathology, surgery)
• Magnetic Resonance Imaging
• Neurosurgical Procedures
• Radiotherapy
• Temozolomide
• Temporal Lobe (pathology, surgery)
• Treatment Outcome