Dynamic changes of IgG subtypes of thyroid peroxidase antibody in patients with postpartum thyroiditis.

Abstract

AIM:

To clarify dynamic changes of IgG subtypes of thyroid peroxidase antibody (TPOAb) during the first postpartum year in Chinese patients diagnosed with postpartum thyroiditis (PPT).

METHODS:

We retrospectively collected serum samples before and 3, 6, 9 and 12 months postpartum from 58 PPT patients. Levels of TPOAb and its IgG subtypes were examined by ELISA.

RESULTS:

Titers of total TPOAb and its IgG subtypes were lowest before delivery in PPT patients. Following delivery, titers of total TPOAb increased. Concentrations of IgG1 and IgG4 subtypes increased for 3 months postpartum, then became stable. Concentrations of the IgG2 subtype increased gradually until 9 months postpartum. Concentrations of the IgG3 subtype reached a peak at 6 months postpartum and remained at a high level thereafter. In PPT patients with an episode of hypothyroidism, levels of total TPOAb and of the IgG subtypes as well as the IgG1/IgG4 ratios were significantly higher than those in patients with an episode of hyperthyroidism and normal controls. Correlations between titers of TPOAb and thyroid-stimulating hormone levels (positive) and free T(4) levels (negative) were seen 6 months postpartum.

CONCLUSION:

TPOAb is related to thyroid injury and the IgG1 subtype of TPOAb may play a major role in the damage of the thyroid in PPT.

• Authors: Di Teng, Chenyang Li, Ying Teng, Yuhong Ouyang, Yushu Li, Weiping Teng
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 69 Issue 1 Pg. 24-9 ( 2010) ISSN: 1423-002X [Electronic] Switzerland
• PMID: 19829002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• Immunoglobulin Isotypes
• Iodide Peroxidase

Topics

• China
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin Isotypes (blood, immunology)
• Iodide Peroxidase (blood, immunology)
• Postpartum Period
• Postpartum Thyroiditis (enzymology, immunology)
• Retrospective Studies
• Statistics, Nonparametric