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Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease.

Abstract
Serious respiratory depression may occur in patients with chronic obstructive pulmonary disease (COPD), receiving hypnotics during acute exacerbations. However, in a previous study on oxygenation during sleep in patients with stable hypoxemic non-hypercapnic COPD, we were unable to demonstrate a significant negative effect from single doses of nitrazepam and flunitrazepam. We have now investigated the effects of propiomazine, a phenothiazine hypnotic, in a double-blind randomized cross-over study of oxygen saturation and apneas during sleep and other sleep variables in 12 non-obese hypoxemic but clinically stable theophylline-treated COPD patients (PaO2 8.1 kPa, PaCO2 5.6 kPa, FEV1 31% of predicted value). None of the respiratory variables were adversely affected by a single oral dose of 25 mg propiomazine, whereas total sleeping time and the sleep efficiency index increased.
AuthorsB Midgren, L Hansson, S Ahlmann, D Elmqvist
JournalRespiration; international review of thoracic diseases (Respiration) Vol. 57 Issue 4 Pg. 239-42 ( 1990) ISSN: 0025-7931 [Print] Switzerland
PMID1982774 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Phenothiazines
  • Oxygen
Topics
  • Double-Blind Method
  • Female
  • Humans
  • Lung Diseases, Obstructive (physiopathology)
  • Male
  • Middle Aged
  • Oxygen (blood)
  • Phenothiazines (pharmacology)
  • Respiration (drug effects)
  • Sleep (drug effects)

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