Abstract |
Serious respiratory depression may occur in patients with chronic obstructive pulmonary disease ( COPD), receiving hypnotics during acute exacerbations. However, in a previous study on oxygenation during sleep in patients with stable hypoxemic non-hypercapnic COPD, we were unable to demonstrate a significant negative effect from single doses of nitrazepam and flunitrazepam. We have now investigated the effects of propiomazine, a phenothiazine hypnotic, in a double-blind randomized cross-over study of oxygen saturation and apneas during sleep and other sleep variables in 12 non-obese hypoxemic but clinically stable theophylline-treated COPD patients (PaO2 8.1 kPa, PaCO2 5.6 kPa, FEV1 31% of predicted value). None of the respiratory variables were adversely affected by a single oral dose of 25 mg propiomazine, whereas total sleeping time and the sleep efficiency index increased.
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Authors | B Midgren, L Hansson, S Ahlmann, D Elmqvist |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 57
Issue 4
Pg. 239-42
( 1990)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 1982774
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Double-Blind Method
- Female
- Humans
- Lung Diseases, Obstructive
(physiopathology)
- Male
- Middle Aged
- Oxygen
(blood)
- Phenothiazines
(pharmacology)
- Respiration
(drug effects)
- Sleep
(drug effects)
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