Abstract |
Four abietane diterpenoids were isolated from the methanolic extract of the roots of Meriandera benghalensis and tested for their biological activity. Cryptotanshinone (2) and 17-hydroxycryptotanshinone (4) are known metabolites however the occurrence of tanshinone IIA (1) and przewaquinone A (3) from Meriandera benghalensis is reported for the first time. The four diterpenoids were identified by MS and one- and two dimensional NMR experiments. The isolated compounds were tested for their in vitro antiproliferative activity against three human cancer cell lines (a lung cancer (A-427), a urinary bladder cancer (5637) and a breast cancer (MCF-7) cell line) and for their antibacterial effect against three Gram-positive bacterial strains. All four abietanes showed potent cytotoxic effect against all cancer cell lines (IC50 between 1 and 8 microM) as well as antibacterial effect against the bacteria tested (MIC values between 33 and 70 microM).
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Authors | R A A Mothana, R Jansen, R Gruenert, P J Bednarski, U Lindequist |
Journal | Die Pharmazie
(Pharmazie)
Vol. 64
Issue 9
Pg. 613-5
(Sep 2009)
ISSN: 0031-7144 [Print] Germany |
PMID | 19827307
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Abietanes
- Anti-Infective Agents
- Antineoplastic Agents, Phytogenic
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Topics |
- Abietanes
(isolation & purification, pharmacology)
- Anti-Infective Agents
(isolation & purification, pharmacology)
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology)
- Cell Line, Tumor
- Gram-Positive Bacteria
(drug effects)
- Humans
- Lamiaceae
(chemistry)
- Mass Spectrometry
- Microbial Sensitivity Tests
- Plant Roots
(chemistry)
- Spectrophotometry, Infrared
- Spectrophotometry, Ultraviolet
- Structure-Activity Relationship
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