HIV fusion inhibitors.

Abstract

Drugs based on amino acid sequence of Heptad Repeats of gp41 of HIV have been explored in search of anti-HIV drugs acting by inhibition of the gp41 6-helix formation and subsequent cellular infection. These are classified under a distinct discipline called HIV fusion inhibitors. Resistance to HIV fusion inhibitors and their solutions have also been discussed in this review.

• Authors: M I Qadir, S A Malik
• Journal: Reviews in medical virology (Rev Med Virol) Vol. 20 Issue 1 Pg. 23-33 (Jan 2010) ISSN: 1099-1654 [Electronic] England
• PMID: 19827030 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• HIV Envelope Protein gp41
• HIV Fusion Inhibitors

Topics

• Amino Acid Sequence
• Drug Resistance, Viral
• HIV (drug effects, physiology)
• HIV Envelope Protein gp41 (antagonists & inhibitors, genetics)
• HIV Fusion Inhibitors (pharmacology, therapeutic use)
• HIV Infections (drug therapy, virology)
• Humans
• Membrane Fusion (drug effects)
• Molecular Sequence Data