Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties.

Abstract	Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS-induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30-100mg/kg os) and trans-cinnamaldehyde (10mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O.quixos essential oil.
Authors	Vigilio Ballabeni, Massimiliano Tognolini, Carmine Giorgio, Simona Bertoni, Renato Bruni, Elisabetta Barocelli
Journal	Fitoterapia (Fitoterapia) Vol. 81 Issue 4 Pg. 289-95 (Jun 2010) ISSN: 1873-6971 [Electronic] Netherlands
PMID	19825398 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	(c) 2009 Elsevier B.V. All rights reserved.
Chemical References	Anti-Inflammatory Agents Antineoplastic Agents, Phytogenic Cinnamates Inflammation Mediators Lipopolysaccharides Oils, Volatile Plant Extracts methyl cinnamate Acrolein Carrageenan cinnamaldehyde
Topics	Acrolein (analogs & derivatives, isolation & purification, pharmacology, therapeutic use) Animals Anti-Inflammatory Agents (isolation & purification, pharmacology, therapeutic use) Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology, therapeutic use) Carrageenan Cell Line, Tumor Cinnamates Edema (chemically induced, drug therapy) Gastric Mucosa (drug effects) Humans Inflammation Mediators (metabolism) Lipopolysaccharides Macrophages (drug effects) Male Neuroblastoma (drug therapy) Ocotea (chemistry) Oils, Volatile (chemistry, pharmacology, therapeutic use) Phytotherapy Plant Extracts (chemistry, pharmacology, therapeutic use) Rats Rats, Wistar

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