Abstract |
Given their antileukemic activity, natural killer (NK) cells can alter the outcome of hematopoietic stem cell transplantation (HSCT). The physiologic functions of NK cells are regulated by the interaction of killer immunoglobulin-like receptors (KIR) with specific HLA class I ligands. In the literature, different models based on HLA class I and/or KIR donor (D)/recipient (R) gene disparities are considered as predictors of NK cell alloreactivity. In this retrospective and multicentric French study, we analyzed the clinical impact of the different NK-alloreactivity models in 264 patients who underwent T repleted unrelated HSCT. First, we did not observe that the "KIR ligand- ligand" model had a significant clinical impact on unrelated HSCT outcome, whereas the "missing KIR ligand" model had a significant but limited effect on unrelated HSCT, because only the absence of C1 ligand in patients with myelogenous diseases was associated with a decreased overall survival (OS) (hazard ratio=2.17, P=.005). The " KIR receptor-receptor" and the " KIR receptor- ligand" models seemed the most capable of predicting NK alloreactivity because they had a significant impact on acute graft-versus-host disease (aGVHD) occurrence, OS, and relapse incidence in D/R unrelated pairs. In particular, KIR3DL1 gene mismatches in the GVH direction (D(+)R(-)) and the D KIR3DL1(+)/3DS1(+) and R Bw4(-) combination were respectively correlated with the lowest OS in HLA identical pairs (HR=1.99, P =.02) and the highest incidence of relapse in HLA nonidentical D/R unrelated pairs (HR=4.72, P =.03). Overall, our results suggest a detrimental effect of KIR3DL1(+)/3DS1(+) donor NK cells transplanted into HLA-Bw4(-) patients in the absence of an educational process via KIR3DL1/ HLA-Bw4 interactions.
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Authors | Katia Gagne, Marc Busson, Jean-Denis Bignon, Marie-Lorraine Balère-Appert, Pascale Loiseau, Anne Dormoy, Valérie Dubois, Pascale Perrier, Isabelle Jollet, Monique Bois, Dominique Masson, Agnès Moine, Léna Absi, Didier Blaise, Dominique Charron, Colette Raffoux, ARS2000 FRM and FGM group |
Journal | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
(Biol Blood Marrow Transplant)
Vol. 15
Issue 11
Pg. 1366-75
(Nov 2009)
ISSN: 1523-6536 [Electronic] United States |
PMID | 19822295
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- HLA-B Antigens
- HLA-Bw4 antigen
- KIR3DL1 protein, human
- Ligands
- Receptors, KIR3DL1
- Receptors, KIR3DS1
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Topics |
- Adolescent
- Adult
- Biomarkers
- Bone Marrow Diseases
(surgery)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- HLA-B Antigens
(analysis)
- Hematologic Neoplasms
(surgery)
- Hematopoietic Stem Cell Transplantation
- Histocompatibility
- Humans
- Infant
- Killer Cells, Natural
(immunology)
- Ligands
- Living Donors
- Male
- Middle Aged
- Models, Immunological
- Prognosis
- Receptors, KIR3DL1
(genetics)
- Receptors, KIR3DS1
(genetics)
- Recurrence
- Retrospective Studies
- Survival Analysis
- Transplantation, Homologous
(immunology)
- Treatment Outcome
- Young Adult
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