Association between obesity and the risk of malignant lymphoma in Japanese: a case-control study.

Abstract

Although marked differences in anthropometric characteristics and malignant lymphoma (ML) incidence suggest that the association between obesity and ML risk in Asian and non-Asian populations may differ, few studies have investigated this association in Asian populations. Here, we conducted a sex- and age-matched case-control study in a Japanese population using 782 cases and 3,910 noncancer controls in the hospital-based Epidemiological Research Program at Aichi Cancer Center Hospital. Odds ratios (ORs) and 95% confidence intervals (CIs) for anthropometric characteristics were estimated using a conditional logistic regression model that incorporated smoking and alcohol intake. Recent body weight and body mass index (BMI) showed marginally significant association with ML risk (ORs [95% CIs] per 5-unit increase in recent weight and BMI; 1.04 [0.99-1.09] and 1.11 [0.98-1.27], respectively). On the other hand, weight and BMI in early adulthood exhibited a strong association with ML risk (ORs [95% CIs] per 5-unit increase in early adulthood weight and BMI; 1.11 [1.05-1.18] and 1.33 [1.13-1.55], respectively). Further, in women, a BMI of 25.0-29.9 kg/m(2), defined as obesity in Asian populations, during early adulthood was significantly associated with ML risk compared to the normal range of 18.5-22.9 kg/m(2). By histological ML subtype, the point estimates of ORs for obesity relative to normal weight in early adulthood were over unity for non-Hodgkin lymphoma (NHL) as a whole and significant for diffuse large B-cell lymphoma (DLBCL). In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL.

• Authors: Junya Kanda, Keitaro Matsuo, Takeshi Suzuki, Satoyo Hosono, Hidemi Ito, Tatsuo Ichinohe, Masao Seto, Yasuo Morishima, Kazuo Tajima, Hideo Tanaka
• Journal: International journal of cancer (Int J Cancer) Vol. 126 Issue 10 Pg. 2416-25 (May 15 2010) ISSN: 1097-0215 [Electronic] United States
• PMID: 19821488 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Age Distribution
• Age Factors
• Aged
• Aged, 80 and over
• Asian People (statistics & numerical data)
• Body Mass Index
• Body Weight
• Case-Control Studies
• Confidence Intervals
• Female
• Hodgkin Disease (epidemiology, etiology)
• Humans
• Japan (epidemiology)
• Logistic Models
• Lymphoma (epidemiology, etiology)
• Lymphoma, Non-Hodgkin (epidemiology, etiology)
• Male
• Middle Aged
• Obesity (complications)
• Odds Ratio
• Risk Assessment
• Risk Factors
• Sex Distribution
• Young Adult