Effect of tiacrilast, a mast cell mediator-release inhibitor, on murine experimental contact dermatitis.

Abstract	The effect of tiacrilast, a mast cell mediator-release inhibitor, was studied in dinitrofluorobenzene-induced allergic and croton oil- or dimethyl sulfoxide-induced irritant murine contact dermatitis. At 1% concentration, the compound significantly reduced the ear swelling in both allergic and irritant dermatitis and preserved the mast cell architecture on histopathology. These findings suggest that mast cells participate in the elicitation of murine contact dermatitis.
Authors	M Csatò, R Judák, B Bozóky, B M Czarnetzki
Journal	Skin pharmacology : the official journal of the Skin Pharmacology Society (Skin Pharmacol) Vol. 3 Issue 3 Pg. 164-70 ( 1990) ISSN: 1011-0283 [Print] Switzerland
PMID	1981832 (Publication Type: Journal Article)
Chemical References	Histamine H1 Antagonists Quinazolines tiacrilast Croton Oil Dinitrofluorobenzene Dimethyl Sulfoxide
Topics	Animals Croton Oil (adverse effects) Dermatitis, Contact (drug therapy) Dimethyl Sulfoxide (adverse effects) Dinitrofluorobenzene (adverse effects) Female Histamine H1 Antagonists (therapeutic use) Mice Quinazolines (therapeutic use)

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