Abstract | BACKGROUND: METHODS: Sixty patients planned to undergo unilateral osteotomy of the first metatarsal as a day surgery procedure were randomized to receive pre-operatively and 24 h afterwards, orally either dexamethasone 9 mg or placebo. For pain medication, paracetamol and oxycodone capsules for rescue medication were given. The study ended on the evening of the third post-operative day (POD). The primary endpoint was the cumulative oxycodone consumption. Secondary endpoints were maximal pain scores before oxycodone intake and daily oxycodone doses. In addition, adverse effects were documented. RESULTS: Twenty-five patients in both groups completed the study. The total median (range) oxycodone consumption during the study period was 45 (0-165) mg in the dexamethasone group and 78 (15-175) mg in the placebo group (P=0.049). The major differences in oxycodone consumption were seen on PODs 0-1. In the dexamethasone group, patients reported significantly lower pain scores on PODs 0-1, and significantly less nausea on POD 1. On PODs 2-3 no differences were seen. However, at 2 weeks post-operatively, patient satisfaction to drug therapy did not differ - in both groups 81% would have chosen the same medication again. CONCLUSION:
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Authors | K Mattila, V K Kontinen, E Kalso, M J Hynynen |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 54
Issue 3
Pg. 268-76
(Mar 2010)
ISSN: 1399-6576 [Electronic] England |
PMID | 19817718
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Anti-Inflammatory Agents
- Acetaminophen
- Dexamethasone
- Oxycodone
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Topics |
- Acetaminophen
(therapeutic use)
- Adult
- Ambulatory Surgical Procedures
- Analgesics, Non-Narcotic
(therapeutic use)
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Anesthesia, Spinal
- Anti-Inflammatory Agents
(therapeutic use)
- Dexamethasone
(therapeutic use)
- Double-Blind Method
- Endpoint Determination
- Female
- Hallux Valgus
(surgery)
- Humans
- Male
- Metatarsal Bones
(surgery)
- Middle Aged
- Osteotomy
- Oxycodone
(administration & dosage, therapeutic use)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Postoperative Nausea and Vomiting
(epidemiology)
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