Evaluation of oxidant-antioxidant balance in patients on maintenance haemodialysis: a comparative study of dialyzers membranes.

Abstract

BACKGROUND:

Haemodialysis (HD) exacerbates oxidative stress (OS). The polymethyl-methacrylate (PMMA)-BK-F membrane ameliorates OS and inflammation markers compared to polyacrylonitrile (PAN/AN69) and cellulose membranes. This may be due to the size of pore radius, high flux or other specific properties of PMMA membranes.

AIM:

To compare OS and inflammatory status in HD-treated end stage renal disease patients with membranes of different pore size radius and flux.

METHODS:

47 patients of both sexes were studied. The HD membranes with which the patients were normally treated were changed to BK-P or B-3 membranes for 6 months. Intracellular and extracellular components of the oxidant-antioxidant balance (OAB), C-reactive protein (CRP), beta2-micro-globulin (beta2mu-globulin), albumin and transferrin were measured.

RESULTS:

A significant decrease in red cell membrane thiobarbituric acid reacting substances and an increase in cytosolic superoxide dismutase (SOD) and plasma total antioxidant substances were observed in all patients after 6 months of treatment with BK-P and B-3 membranes except SOD and CRP in patients previously dialysed with triacetate cellulose membranes. Albumin and transferrin remained unmodified. beta2mu-globulin significantly decreased after treatment with PMMA membranes.

CONCLUSION:

BK-P and B-3 HD membranes improved the OAB, beta2mu-globulin and CRP compared to PAN/AN69 and cellulose diacetate membranes.

• Authors: Juan F Macías Núñez, Zoubiair Ghais, Jesus Bustamante, Jose M Lopez-Novoa, J Arrieta, G Barril, María D Del Pino, C Escaja, I M Martín, C Fernández Andrade, F García, J Núñez, J M Onaindía, J González, M Pérez-Prieto, M Fernández, J Lopez, J M Santiago, M Vicens, F Sousa
• Journal: Nephron. Clinical practice (Nephron Clin Pract) Vol. 114 Issue 1 Pg. c67-73 ( 2010) ISSN: 1660-2110 [Electronic] Switzerland
• PMID: 19816045 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• Membranes, Artificial
• Serum Albumin
• Transferrin
• beta 2-Microglobulin
• C-Reactive Protein
• Superoxide Dismutase

Topics

• Adult
• Aged
• C-Reactive Protein (analysis)
• Comorbidity
• Equipment Design
• Female
• Humans
• Kidney Failure, Chronic (epidemiology, metabolism, therapy)
• Male
• Membranes, Artificial
• Middle Aged
• Oxidative Stress (physiology)
• Renal Dialysis
• Serum Albumin (analysis)
• Superoxide Dismutase (metabolism)
• Transferrin (analysis)
• beta 2-Microglobulin (blood)