Dynamic regulation of the endocannabinoid system: implications for analgesia.

Abstract

The analgesic effects of cannabinoids are well documented, but these are often limited by psychoactive side-effects. Recent studies indicate that the endocannabinoid system is dynamic and altered under different pathological conditions, including pain states. Changes in this receptor system include altered expression of receptors, differential synthetic pathways for endocannabinoids are expressed by various cell types, multiple pathways of catabolism and the generation of biologically active metabolites, which may be engaged under different conditions. This review discusses the evidence that pain states alter the endocannabinoid receptor system at key sites involved in pain processing and how these changes may inform the development of cannabinoid-based analgesics.

• Authors: Devi Rani Sagar, A Gemma Gaw, Bright N Okine, Stephen G Woodhams, Amy Wong, David A Kendall, Victoria Chapman
• Journal: Molecular pain (Mol Pain) Vol. 5 Pg. 59 (Oct 08 2009) ISSN: 1744-8069 [Electronic] United States
• PMID: 19814807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cannabinoid Receptor Modulators
• Cannabinoids
• Endocannabinoids
• Peroxisome Proliferator-Activated Receptors
• Amidohydrolases
• fatty-acid amide hydrolase

Topics

• Amidohydrolases (metabolism)
• Analgesia
• Animals
• Cannabinoid Receptor Modulators (biosynthesis, metabolism)
• Cannabinoids (metabolism)
• Endocannabinoids
• Humans
• Pain (metabolism)
• Peroxisome Proliferator-Activated Receptors (metabolism)