A high dose of intravenous immunoglobulin increases CD94 expression on natural killer cells in women with recurrent spontaneous abortion.

Abstract

PROBLEM:

A high dose of intravenous immunoglobulin (HIVIg) therapy is effective in various diseases such as autoimmune diseases, and also is expected to have efficacy in recurrent spontaneous abortion (RSA). The aim of this study was to understand immunological mechanisms of this therapy.

METHOD OF STUDY:

By flowcytometric analyses, we examined phenotypic changes of a variety of immunological cells including natural killer (NK) cells, cytotoxic T cells, regulatory T cells and macrophages in peripheral blood of RSA women with HIVIg therapy (n = 8).

RESULTS:

Expression percentages of inhibitory CD94 on NK cells significantly (P = 0.01) increased after the therapy (58.8 +/- 21.4% versus 71.0 +/- 17.6%).

CONCLUSION:

Mechanisms of possible efficacy of HIVIg therapy for RSA may include enhancement of CD94 expression and subsequent suppression of NK cell cytotoxicity.

• Authors: Shigeki Shimada, Masamitsu Takeda, Jun Nishihira, Masanori Kaneuchi, Noriaki Sakuragi, Hisanori Minakami, Hideto Yamada
• Journal: American journal of reproductive immunology (New York, N.Y. : 1989) (Am J Reprod Immunol) Vol. 62 Issue 5 Pg. 301-7 (Nov 2009) ISSN: 1600-0897 [Electronic] Denmark
• PMID: 19811464 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulins, Intravenous
• NK Cell Lectin-Like Receptor Subfamily D

Topics

• Abortion, Habitual (blood, drug therapy, immunology)
• Adult
• Female
• Gene Expression Regulation (immunology)
• Humans
• Immunoglobulins, Intravenous (administration & dosage)
• Immunophenotyping
• Killer Cells, Natural (drug effects, immunology, metabolism, pathology)
• Macrophages (drug effects, immunology, metabolism, pathology)
• NK Cell Lectin-Like Receptor Subfamily D (genetics, immunology, metabolism)
• Pregnancy
• T-Lymphocytes, Cytotoxic (drug effects, immunology, metabolism, pathology)
• T-Lymphocytes, Regulatory (drug effects, immunology, metabolism, pathology)
• Treatment Outcome