HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Antiepileptic drugs in the treatment of neuropathic pain.

Abstract
Antiepileptic drugs were initially designed to treat epileptic seizures, but are increasingly used in the treatment of neuropathic pain. Efficacy of the newer antiepileptic drugs has been confirmed in placebo-controlled studies for trigeminal neuralgia, postherpetic neuralgia, painful polyneuropathy and central poststroke pain. While standard antiepileptic drugs act as sodium channel blockers, the newer antiepileptics display additional mechanisms of action, including a potentiation of GABAergic inhibition, specific binding on a subtype of calcium channels, a reduced release of glutamate and a blockade of AMPA/kainate receptors. These mechanisms could account for their antiallodynic and antihyperalgesic effects demonstrated in animal models of neuropathic pain and also suggested for gabapentin and lamotrigine in humans. Additional studies are required to compare efficacy of newer versus standard antiepileptic drugs and to better define their place in comparison with other analgesics in the treatment of neuropathic pain.
AuthorsN Attal
JournalExpert review of neurotherapeutics (Expert Rev Neurother) Vol. 1 Issue 2 Pg. 199-206 (Nov 2001) ISSN: 1744-8360 [Electronic] England
PMID19811032 (Publication Type: Journal Article)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: