Systems metabolic effects of a necator americanus infection in Syrian hamster.
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| Abstract |
Hookworms (Ancylostoma duodenale and Necator americanus) are blood-feeding intestinal nematodes that infect approximately 700 million people worldwide. To further our understanding of the systems metabolic response of the mammalian host to hookworm infection, we employed a metabolic profiling strategy involving the combination of (1)H NMR spectroscopic analysis of urine and serum and multivariate data analysis techniques to investigate the biochemical consequences of a N. americanus infection in the hamster. The infection was characterized by altered energy metabolism, consistent with hookworm-induced anemia. Additionally, disturbance of gut microbiotal activity was associated with a N. americanus infection, manifested in the alterations of microbial-mammalian cometabolites, including phenylacetylglycine, p-cresol glucuronide, 4-hydroxy-3-methyl-phenylpropionic acid, hippurate, 4-hydroxyphenylactate, and dimethylamine. The correlation between worm burden and metabolite concentrations also reflected a changed energy metabolism and gut microbial state. Furthermore, elevated levels of urinary 2-aminoadipate was a characteristic feature of the infection, which may be associated with the documented neurological consequences of hookworm infection.
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| Authors | Yulan Wang, Shu-Hua Xiao, Jian Xue, Burton H Singer, Jürg Utzinger, Elaine Holmes |
| Journal | Journal of proteome research (J Proteome Res) Vol. 8 Issue 12 Pg. 5442-50 (Dec 2009) ISSN: 1535-3907 [Electronic] United States |
| PMID | 19810771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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