Abstract | BACKGROUND: METHODS: RESULTS: Age at onset of nephrosis, beginning of first and second therapy, sex ratio, duration of nephrosis before first cytotoxic therapy, interval between first and second cytotoxic therapy, number of relapses, cumulative doses of steroids and length of remission off steroids before second therapy were similar between groups. Four patients (36.4%, p<0.05) in group 1 remained in remission for a median 34.0 months, whereas only 1 patient (4.5%) in group 2 did for 53.0 months. Two patients in group 1 and 1 patient in group 2 became infrequent relapsers. Total number of nonrelapsers and infrequent relapsers was higher in group 1 (54.5%, p<0.05) than in group 2 (9.1%). Number of relapses and cumulative doses of steroids were reduced and length of remission off steroids was longer in group 1 than in group 2 (p<0.05). There was no difference between groups in frequency of side effects, and none had serious toxicity. However, the short period of follow-up in our study does not exclude the risk of azoospermia. CONCLUSIONS:
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Authors | Norishi Ueda, Kazuhiro Takahashi, Yuko Akioka, Masafumi Morooka, Akimasa Ogawa, Kazuo Tsuzuki |
Journal | Journal of nephrology
(J Nephrol)
2009 Sep-Oct
Vol. 22
Issue 5
Pg. 610-5
ISSN: 1121-8428 [Print] Italy |
PMID | 19809993
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Alkylating
- Steroids
- Chlorambucil
- Cyclophosphamide
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Topics |
- Adolescent
- Antineoplastic Agents, Alkylating
(therapeutic use)
- Child
- Child, Preschool
- Chlorambucil
(therapeutic use)
- Cyclophosphamide
(therapeutic use)
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Female
- Humans
- Infant
- Male
- Nephrosis, Lipoid
(drug therapy)
- Remission Induction
- Retrospective Studies
- Secondary Prevention
- Steroids
(therapeutic use)
- Treatment Outcome
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