Antibody responses in normal infants and in infants receiving chemotherapy for congenital neuroblastoma.

Abstract

Three infants with congenital neuroblastoma received a primary series of diptheria-pertassis-tetanus (DPT) immunizations during and after courses of chemotherapy with immunosuppressive medications. Serum IgG, IgA and IgM levels and antidiphthria and antitetanus antibody responses were measured and compared with those of normal infants of similar age. Protective levels of antibody were achieved by the study patients as well as by the control group. These results support the view that children with malignancies who are receiving chemotherapy should not be denied immunization with inactivated vaccines.

• Authors: H A Orgel, R N Hamburger, L M Mendelson, J R Miller, F H Kung
• Journal: Cancer (Cancer) Vol. 40 Issue 3 Pg. 994-7 (Sep 1977) ISSN: 0008-543X [Print] United States
• PMID: 198094 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Bacterial
• Antineoplastic Agents
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M

Topics

• Antibodies, Bacterial (biosynthesis)
• Antineoplastic Agents (therapeutic use)
• Bordetella pertussis (immunology)
• Clostridium tetani (immunology)
• Corynebacterium diphtheriae (immunology)
• Female
• Humans
• Immunization
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)
• Immunoglobulin M (analysis)
• Infant
• Infant, Newborn
• Infant, Newborn, Diseases (drug therapy, immunology)
• Male
• Neuroblastoma (congenital, drug therapy, immunology)