Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy.

Abstract

Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.

• Authors: Sarah E McClelland, Rebecca A Burrell, Charles Swanton
• Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 8 Issue 20 Pg. 3262-6 (Oct 15 2009) ISSN: 1551-4005 [Electronic] United States
• PMID: 19806022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Taxoids

Topics

• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Chromosomal Instability
• Chromosome Segregation
• Drug Resistance, Neoplasm
• Humans
• Kinetochores
• Mitosis
• Neoplasms (drug therapy)
• Taxoids (pharmacology)