Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans.

Abstract

The selective 5-HT1A receptor ligand ipsapirone (IPS) caused dose-related hypothermia in humans. The response was attenuated by the nonselective 5-HT1/2 receptor antagonist metergoline and was completely antagonized by the nonselective beta-adrenoceptor antagonist pindolol, which interacts stereoselectively with the 5-HT1A receptor. The selective beta 1-adrenergic antagonist betaxolol had no effect. The findings indicate that IPS-induced hypothermia specifically involves activation of (presynaptic) 5-HT1A receptors. Therefore, the hypothermic response to IPS may provide a convenient in vivo paradigma to assess the function of the presynaptic 5-HT receptor in affective disorders and its involvement in the effects of psychotropic drugs.

• Authors: K P Lesch, B Poten, K Söhnle, H M Schulte
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 39 Issue 1 Pg. 17-9 ( 1990) ISSN: 0031-6970 [Print] Germany
• PMID: 1980461 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Pyrimidines
• Receptors, Serotonin
• Serotonin Antagonists
• Metergoline
• ipsapirone
• Pindolol
• Betaxolol

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Adult
• Betaxolol (pharmacology)
• Body Temperature (drug effects)
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Metergoline (pharmacology)
• Pindolol (pharmacology)
• Pyrimidines (pharmacology)
• Receptors, Serotonin (drug effects, physiology)
• Serotonin Antagonists (pharmacology)