Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD).

Abstract

We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B(12), cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory diseases, whereas vitamin B(12) derivatives are often beneficial in their treatment. We found that cob(II)alamin reacts with superoxide at rates approaching those of superoxide dismutase itself, suggesting a probable mechanism by which vitamin B(12) protects against chronic inflammation and modulates redox homeostasis.

• Authors: Edward Suarez-Moreira, June Yun, Catherine S Birch, John H H Williams, Andrew McCaddon, Nicola E Brasch
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 131 Issue 42 Pg. 15078-9 (Oct 28 2009) ISSN: 1520-5126 [Electronic] United States
• PMID: 19799418 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Superoxides
• Superoxide Dismutase
• Vitamin B 12

Topics

• Cells, Cultured
• Homeostasis
• Humans
• Kinetics
• Oxidation-Reduction
• Superoxide Dismutase (metabolism)
• Superoxides (chemistry, metabolism)
• Vitamin B 12 (chemistry, metabolism)