Behavioural actions of the serotonergic anxiolytic indorenate.

Abstract

Several recent studies have shown that the 5-HT1A agonist indorenate possesses antianxiety properties. In the present study we report on other behavioural actions of this drug. Indorenate (31.6 mg/kg) induced flat body posture, forepaw treading and hind limb abduction, behavioural characteristics of the serotonin syndrome. After indorenate injection these same behaviours were observed in animals pretreated with p-chlorophenylalanine (400 mg/kg X 3 days), suggesting that the action of this compound is not mediated via serotonin release. The beta-5-HT1 blockers, (-) pindolol (2 mg/kg) or (-) alprenolol (5 mg/kg), did not prevent the actions of indorenate on the serotonin syndrome. Indorenate (10 mg/kg) stimulated the masculine sexual behaviour by reducing the number of intromissions preceding ejaculation. Higher doses (17.8 mg/kg) cause a complete inhibition of sexual behaviour. (-) Pindolol (2 mg/kg) or (-) alprenolol (5 mg/kg) did not antagonize the facilitatory actions of indorenate on male sexual behaviour. A high dose of indorenate (31.6 mg/kg) resulted in an impairment of the motor coordination as tested in a treadmill apparatus. These data reveal that indorenate possesses, in addition to its antianxiety effects, other behavioural characteristics that, however, appear at higher dose levels.

• Authors: A Fernández-Guasti, A Escalante, E Hong, A Agmo
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 37 Issue 1 Pg. 83-8 (Sep 1990) ISSN: 0091-3057 [Print] United States
• PMID: 1979877 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Anxiety Agents
• Receptors, Serotonin
• 5-Methoxytryptamine
• Alprenolol
• indorenate
• Pindolol
• Fenclonine

Topics

• 5-Methoxytryptamine (analogs & derivatives, pharmacology)
• Alprenolol (pharmacology)
• Animals
• Anti-Anxiety Agents (pharmacology)
• Behavior, Animal (drug effects)
• Dose-Response Relationship, Drug
• Fenclonine (pharmacology)
• Male
• Pindolol (pharmacology)
• Psychomotor Performance (drug effects)
• Rats
• Rats, Inbred Strains
• Receptors, Serotonin (drug effects)
• Sexual Behavior, Animal (drug effects)
• Single-Blind Method