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Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings.

Abstract
The objective of this study was to evaluate the effect of pregabalin in painful cervical or lumbosacral radiculopathy treated in Primary Care settings under routine clinical practice. An observational, prospective 12-week secondary analysis was carried-out. Male and female above 18 years, naïve to PGB, with refractory chronic pain secondary to cervical/lumbosacral radiculopathy were enrolled. SF-MPQ, Sheehan Disability Inventory, MOS Sleep Scale, Hospital Anxiety and Depression Scale and the EQ-5D were administered. A total of 490 (34%) patients were prescribed PGB-monotherapy, 702 (48%) received PGB add-on, and 159 (11%) were administered non-PGB drugs. After 12 weeks, significant improvements in pain, associated symptoms of anxiety, depression and sleep disturbances, general health; and level of disability were observed in the three groups, being significantly greater in PGB groups. In routine medical practice, monotherapy or add-on pregabalin is associated with substantial pain alleviation and associated symptoms improvements in painful cervical or lumbosacral radiculopathy.
AuthorsMaría Teresa Saldaña, Ana Navarro, Concepción Pérez, Xavier Masramón, Javier Rejas
JournalRheumatology international (Rheumatol Int) Vol. 30 Issue 8 Pg. 1005-15 (Jun 2010) ISSN: 1437-160X [Electronic] Germany
PMID19798503 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Pregabalin
  • gamma-Aminobutyric Acid
Topics
  • Adult
  • Aged
  • Analgesics (administration & dosage)
  • Evidence-Based Medicine
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neuralgia (drug therapy)
  • Pregabalin
  • Primary Health Care
  • Prospective Studies
  • Radiculopathy (drug therapy)
  • Spondylosis (drug therapy)
  • Treatment Outcome
  • gamma-Aminobutyric Acid (administration & dosage, analogs & derivatives)

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