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Durable hypogammaglobulinemia associated with thymoma (Good syndrome).

Abstract
Good syndrome, characterized by hypogammaglobulinemia and acquired immunodeficiency, is a rare condition associated with thymoma. A 67-year-old woman, who 4 months previously had a thymoma resected, presented with generalized hypogammaglobulinemia with a severely decreased B cell population as demonstrated by flow cytometry. She was diagnosed as having bacterial mediastinitis associated with Good syndrome. For the subsequent 6 years, she suffered from repeated serious bacterial infections. As this paraneoplastic syndrome is not resolved by tumor removal, careful management with intensive infection-control using antibiotics and intravenous immunoglobulins is required for the long term. Serum immunoglobulin levels should be evaluated for patients with thymoma and suspected vulnerability to infection.
AuthorsAtsushi Kitamura, Yuichi Takiguchi, Naobumi Tochigi, Shun-ichi Watanabe, Seiichirou Sakao, Katsushi Kurosu, Nobuhiro Tanabe, Koichiro Tatsumi
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 48 Issue 19 Pg. 1749-52 ( 2009) ISSN: 1349-7235 [Electronic] Japan
PMID19797831 (Publication Type: Case Reports, Journal Article)
Topics
  • Agammaglobulinemia (complications, immunology)
  • Aged
  • B-Lymphocytes (immunology)
  • Female
  • Humans
  • Immunologic Deficiency Syndromes (complications, immunology)
  • Lymphopenia (complications, immunology)
  • Paraneoplastic Syndromes (complications, immunology)
  • Syndrome
  • Thymoma (complications, diagnosis, immunology)
  • Thymus Neoplasms (complications, diagnosis, immunology)
  • Time Factors

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