Abstract | RATIONALE: OBJECTIVE: We sought to investigate the effects of secretoneurin on therapeutic angiogenesis. METHODS AND RESULTS: CONCLUSIONS: In summary, our data indicate that gene therapy with secretoneurin induces therapeutic angiogenesis, arteriogenesis, and vasculogenesis in the hindlimb ischemia model by a nitric oxide-dependent mechanism.
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Authors | Wilfried Schgoer, Markus Theurl, Johannes Jeschke, Arno G E Beer, Karin Albrecht, Roland Gander, Song Rong, Danijela Vasiljevic, Margot Egger, Anna Maria Wolf, Silke Frauscher, Bernhard Koller, Ivan Tancevski, Josef R Patsch, Peter Schratzberger, Hildegunde Piza-Katzer, Andreas Ritsch, Ferdinand H Bahlmann, Reiner Fischer-Colbrie, Dominik Wolf, Rudolf Kirchmair |
Journal | Circulation research
(Circ Res)
Vol. 105
Issue 10
Pg. 994-1002
(Nov 06 2009)
ISSN: 1524-4571 [Electronic] United States |
PMID | 19797703
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inducing Agents
- Cytokines
- Neuropeptides
- Secretogranin II
- secretoneurin
- Nitric Oxide
- Nitric Oxide Synthase Type III
- Nos3 protein, mouse
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Topics |
- Angiogenesis Inducing Agents
(metabolism)
- Animals
- Cytokines
(biosynthesis, genetics)
- Disease Models, Animal
- Endothelial Cells
(metabolism)
- Genetic Therapy
- Hindlimb
(blood supply, metabolism)
- Humans
- Ischemia
(genetics, metabolism, therapy)
- Mice
- Neovascularization, Physiologic
- Neuropeptides
(biosynthesis, genetics)
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase Type III
(biosynthesis)
- Secretogranin II
(biosynthesis, genetics)
- Stem Cells
(metabolism)
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