Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems.

Abstract

In a previous issue of Arthritis Research and Therapy, Ursum and colleagues report the relative stabilities of anticitrullinated protein/peptide antibodies (ACPAs) and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a disease-specific marker of rheumatoid arthritis.

• Authors: Guido Valesini, Cristiano Alessandri
• Journal: Arthritis research & therapy (Arthritis Res Ther) Vol. 11 Issue 5 Pg. 125 ( 2009) ISSN: 1478-6362 [Electronic] England
• PMID: 19796372 (Publication Type: Comment, Editorial, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Autoantigens
• Biomarkers
• Immunoglobulin M
• Citrulline
• Rheumatoid Factor

Topics

• Acute-Phase Reaction (blood, immunology)
• Arthritis, Rheumatoid (blood, immunology)
• Autoantibodies (blood, immunology)
• Autoantigens (immunology)
• Biomarkers (blood)
• Citrulline (blood, immunology)
• Humans
• Immunoglobulin M (blood, immunology)
• Rheumatoid Factor (blood, immunology)