HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Levosulpiride-induced movement disorders.

Abstract
Levosulpiride is a substituted benzamide that is widely used for the management of dyspepsia and emesis. However, little is known about levosulpiride-induced movement disorders (LIM). The aim of this study was to investigate the clinical characteristics of patients with LIM. Among 132 consecutive patients who were diagnosed with drug-induced movement disorders between January 2002 and March 2008, 91 patients with LIM were identified and their medical records reviewed. Seventy-eight (85.7%) patients were aged more than 60 years. The most common LIM was parkinsonism (LIP) (n = 85, 93.4%), followed by tardive dyskinesia (n = 9, 9.9%) and isolated tremor (n = 3, 3.3%). Twenty-one (24.7%) of the 85 patients with LIP were rated as Hoehn and Yahr stage III-V. The oro-lingual area was the only body part that was involved by tardive dyskinesia. LIM persisted after withdrawal of levosulpiride in 48.1% of patients with LIP, 66.7% with dyskinesia, and none with isolated tremor. None of clinical and MRI features predicted the reversibility of LIP. Levosulpiride frequently causes drug-induced movement disorders, presenting mainly with LIP followed by lower face dyskinesia. The symptoms are often severe, and irreversible even after the withdrawal of levosulpiride. Physicians should be cautious in using levosulpiride, especially in elderly patients.
AuthorsHae-Won Shin, Mi J Kim, Jong S Kim, Myoung C Lee, Sun J Chung
JournalMovement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 24 Issue 15 Pg. 2249-53 (Nov 15 2009) ISSN: 1531-8257 [Electronic] United States
PMID19795476 (Publication Type: Journal Article)
Chemical References
  • Antipsychotic Agents
  • Sulpiride
  • levosulpiride
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents (adverse effects)
  • Brain (pathology)
  • Female
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged
  • Movement Disorders (classification, diagnosis, etiology)
  • Parkinson Disease (etiology)
  • Retrospective Studies
  • Sulpiride (adverse effects, analogs & derivatives)
  • Tremor (chemically induced)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: