Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival.

Abstract

To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (INT-1) score according to the international prognostic scoring system and low RPS14 expression had a superior median overall survival of not reached versus 25 months compared to INT-1 patients with high RPS14 expression (p=0.0249). Using multivariate analysis, the RPS14 expression status was confirmed as an independent predictor for survival in INT-1 patients.

• Authors: Akos Czibere, Ingmar Bruns, Bärbel Junge, Raminder Singh, Guido Kobbe, Rainer Haas, Ulrich Germing
• Journal: Haematologica (Haematologica) Vol. 94 Issue 10 Pg. 1453-5 (Oct 2009) ISSN: 1592-8721 [Electronic] Italy
• PMID: 19794090 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Ribosomal Proteins
• ribosomal protein S14

Topics

• Adult
• Aged
• Aged, 80 and over
• Chromosome Aberrations
• Chromosomes, Human, Pair 5 (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Myelodysplastic Syndromes (classification, genetics, mortality)
• Registries
• Ribosomal Proteins (genetics)
• Survival Rate (trends)