Body temperature discriminates between full and partial benzodiazepine receptor agonists.

Abstract

The benzodiazepine full agonist loprazolam and the beta-carboline ZK 93423 produced hypothermia in mice (1-30 mg/kg i.p.). Maximal effects were seen at relatively low doses of these compounds. In contrast, the partial agonists Ro 17-1812 (a benzodiazepine) and ZK 91296 (a beta-carboline), did not modify rectal temperature at doses up to 30 mg/kg i.p. (which would be receptor saturating). Body temperature may therefore be a useful test for discriminating between full and partial agonists at the benzodiazepine receptor.

• Authors: H C Jackson, D J Nutt
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 185 Issue 2-3 Pg. 243-6 (Aug 28 1990) ISSN: 0014-2999 [Print] Netherlands
• PMID: 1979276 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Benzodiazepinones
• Carbolines
• Receptors, GABA-A
• Benzodiazepines
• triazulenone
• ZK 91296
• ZK 93423
• Ro 17-1812

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Benzodiazepines
• Benzodiazepinones (pharmacology)
• Body Temperature (drug effects)
• Carbolines (pharmacology)
• Male
• Mice
• Mice, Inbred Strains
• Receptors, GABA-A (drug effects)