Abstract | BACKGROUND: METHODS: RESULTS: Prostatic enlargement was observed in the HFD-fed rats. Significant increase in the cell proliferation markers confirmed the occurrence of cellular hyperplasia in the prostate of hyperinsulinemic rat. Enhanced alpha- adrenoceptor mediated contraction in the prostate of HFD-fed rats indicates augmented contractility of the gland. Higher level of phosphorylated-ERK suggests enhanced MEK/ERK signaling. HFD feeding has not led to change in the plasma testosterone level. However, testosterone treatment further augmented the prostatic growth in HFD-fed rats. PG treatment led to improved insulin sensitivity, decreased plasma insulin level and prostate weight, indicating the role of compensatory hyperinsulinemia in the prostate growth. CONCLUSIONS: The present investigation reports that HFD-feeding induced hyperinsulinemic condition leads to increased cellular proliferation, enhanced alpha- adrenoceptor mediated contraction, and enlargement of the prostate in rats.
|
Authors | A Vikram, G B Jena, P Ramarao |
Journal | The Prostate
(Prostate)
Vol. 70
Issue 1
Pg. 79-89
(Jan 01 2010)
ISSN: 1097-0045 [Electronic] United States |
PMID | 19790233
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | (c) 2009 Wiley-Liss, Inc. |
Chemical References |
|
Topics |
- Animals
- Cell Proliferation
- Dietary Fats
(administration & dosage, adverse effects)
- Hyperinsulinism
(complications, pathology)
- Insulin Resistance
- Male
- Prostate
(pathology)
- Prostatic Hyperplasia
(etiology, pathology)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
|