Pharmacokinetic study of melamine in rhesus monkey after a single oral administration of a tolerable daily intake dose.

Abstract

To perform pharmacokinetic study of melamine in rhesus monkey, melamine was orally administered to three experimental monkeys at a single dose of 1.4 mg/kg body weight. Plasma and urine were collected for the determination of melamine and cyanuric acid with a liquid chromatography tandem mass spectrometry method. The mean+/-SD area under the concentration-time curve from time zero to 48 h (AUC0-t) was 14,145+/-2002 microg/Lh. The maximum concentration of melamine in plasma (C(max)) was 1767+/-252 microg/L. The time to maximum concentration (T(max)) was 2.67+/-1.16 h and the half-life of melamine in plasma (t(1/2)) was 4.41+/-0.43 h. Following oral administration, melamine was rapidly excreted, mainly through urinary clearance. No significant correlation was found between melamine and cyanuric acid, suggesting that cyanuric acid may not be derived from melamine.

• Authors: Gangyi Liu, Shuijun Li, Jingying Jia, Chengyin Yu, Jian He, Chen Yu, Jianmin Zhu
• Journal: Regulatory toxicology and pharmacology : RTP (Regul Toxicol Pharmacol) Vol. 56 Issue 2 Pg. 193-6 (Mar 2010) ISSN: 1096-0295 [Electronic] Netherlands
• PMID: 19788907 (Publication Type: Comparative Study, Journal Article)
• Copyright: (c) 2009 Elsevier Inc. All rights reserved.

Chemical References

• Triazines
• melamine

Topics

• Administration, Oral
• Animals
• Dose-Response Relationship, Drug
• Female
• Macaca mulatta
• Male
• Time Factors
• Triazines (administration & dosage, pharmacokinetics)