Abstract | OBJECTIVE: To elucidate the background behind the attenuated circadian rhythm of vasoactive hormones in patients with nocturnal enuresis, we tested the hypothesis that enuretic children exhibit an abnormal neuroendocrine response to a baroreflex stimulus during daytime. DESIGN AND PATIENTS: In fifteen children and adolescents (aged 13.4 +/- 0.9 years) with severe nocturnal enuresis and 10 age- and sex-matched healthy controls, we performed a 'daytime supine posture' (DSP) study at 10:00 h. MEASUREMENTS: RESULTS: In both controls and patients with enuresis, DSP at 10:00 h resulted in a marked fall in MAP and HR, a rise in pulse pressure (PP) and estimated plasma volume (PV) and a significant suppression of P(AVP), P(ANGII) and S(ALDO), whereas P(ANP) increased. There were no significant differences between groups in haemodynamic or neuroendocrine responses to DSP. CONCLUSIONS: The study showed that children with nocturnal enuresis exhibit a normal neuroendocrine response to supine posture during daytime indicating that baroregulatory mechanisms per se are not playing a significant pathogenic role. Interestingly, the normal neuroendocrine response to supine posture seems to undergo marked circadian changes, as supine posture at night-time is associated with increased levels of vasoactive hormones.
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Authors | Søren Rittig |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 72
Issue 6
Pg. 781-6
(Jun 2010)
ISSN: 1365-2265 [Electronic] England |
PMID | 19788592
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
- Vasopressins
- Angiotensin II
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Topics |
- Adolescent
- Angiotensin II
(blood, metabolism)
- Blood Pressure
(physiology)
- Body Fluids
(metabolism, physiology)
- Child
- Circadian Rhythm
- Female
- Health
- Heart Rate
(physiology)
- Humans
- Male
- Neurosecretory Systems
(metabolism, physiology)
- Nocturnal Enuresis
(blood, physiopathology)
- Posture
(physiology)
- Supine Position
(physiology)
- Vasopressins
(blood, metabolism)
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