Abstract | BACKGROUND AND AIM: The possible involvement of oxidative stress in hepatitis C virus (HCV)-induced liver damage and hepatocarcinogenesis has been reported. We have recently developed a novel method to measure total hydroxyoctadecadienoic acid (tHODE) and have proposed its usefulness as a biomarker for lipid peroxidation. The present study was undertaken to evaluate oxidative stress in HCV-infected liver diseases by several potential oxidative stress markers including tHODE and further to validate the biomarkers for evaluating the efficacy of iron reduction therapy. METHODS: RESULTS: The concentrations of tHODE in the plasma and erythrocytes and t8-iso-PGF(2alpha) in the plasma of chronic HCV-infected patients were significantly higher than those of healthy controls. Plasma levels of vitamin E and vitamin C of HCV-infected patients were lower than those of the controls. Furthermore, the plasma tHODE significantly correlated with serum aminotransferases and type IV collagen-7S domain in chronic HCV-infected patients. During the iron reduction therapy, the plasma levels of tHODE but not t8-iso-PGF(2alpha) decreased and inversely its stereo-isomer ratio (ZE/EE) increased in parallel with the decreases of serum alanine aminotransferase, ferritin and alpha-fetoprotein. CONCLUSION: The levels of tHODE in chronic HCV-infected patients can be a useful biomarker for the evaluation of oxidative stress in chronic hepatitis C.
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Authors | Yasukazu Yoshida, Yasuharu Imai, Yoshiyuki Sawai, Yoshiro Saito, Jiaofei Cao, Kazuto Fukuda, Etsuo Niki |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 25
Issue 1
Pg. 107-15
(Jan 2010)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 19780883
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Antioxidants
- Biomarkers
- Fatty Acids, Unsaturated
- Hemoglobins
- RNA, Viral
- hydroxyoctadecadienoic acid
- 8-epi-prostaglandin F2alpha
- Ferritins
- Dinoprost
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Topics |
- Aged
- Antioxidants
(metabolism)
- Biomarkers
(blood)
- Dinoprost
(analogs & derivatives, blood)
- Fatty Acids, Unsaturated
(blood)
- Female
- Ferritins
(blood)
- Hemoglobins
(metabolism)
- Hepacivirus
(genetics)
- Hepatitis C
(blood, diagnosis, therapy)
- Humans
- Liver
(metabolism, virology)
- Liver Cirrhosis
(blood, therapy, virology)
- Male
- Middle Aged
- Oxidative Stress
(drug effects)
- Phlebotomy
- Predictive Value of Tests
- Prospective Studies
- RNA, Viral
(blood)
- Reproducibility of Results
- Time Factors
- Treatment Outcome
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