HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Convenient large-scale synthesis of D-glucaro-1,4:6,3-dilactone.

Abstract
Calcium D-glucarate was converted into D-glucaro-1,4:6,3-dilactone on 32-g, 1-kg, and 22-kg scale, using azeotropic distillation with methyl isobutyl ketone to drive the dehydration. The crystalline product was > or = 99.5% pure by GC and NMR, and overall yield was as high as 72%.
AuthorsTroy C Gehret, A Stephen Frobese, James S Zerbe, H Keith Chenault
JournalThe Journal of organic chemistry (J Org Chem) Vol. 74 Issue 21 Pg. 8373-6 (Nov 06 2009) ISSN: 1520-6904 [Electronic] United States
PMID19777999 (Publication Type: Journal Article)
Chemical References
  • D-glucaro-1,4:6,3-dilactone
  • Lactones
  • Glucaric Acid
Topics
  • Crystallization
  • Glucaric Acid (analogs & derivatives, chemical synthesis)
  • Lactones (chemical synthesis)
  • Magnetic Resonance Spectroscopy

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: