Topical chemotherapy for ocular surface squamous neoplasia: current status.

Abstract

Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-alpha2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%-88%). 5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient.

• Authors: Ricardo Sepulveda, Jacob Pe'er, Edoardo Midena, Stefan Seregard, Harminder S Dua, Arun D Singh
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 94 Issue 5 Pg. 532-5 (May 2010) ISSN: 1468-2079 [Electronic] England
• PMID: 19776089 (Publication Type: Journal Article, Review)

Chemical References

• Antibiotics, Antineoplastic
• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Mitomycin
• Fluorouracil

Topics

• Administration, Topical
• Antibiotics, Antineoplastic (administration & dosage)
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents (administration & dosage)
• Eye Neoplasms (drug therapy)
• Fluorouracil (administration & dosage)
• Humans
• Interferon alpha-2
• Interferon-alpha (administration & dosage)
• Mitomycin (administration & dosage)
• Neoplasms, Squamous Cell (drug therapy)
• Recombinant Proteins