Adsorption of the Pt(II) anticancer drug carboplatin by mesoporous silica.

Abstract

MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O')(NH3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8+/-0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mM drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k(1)=2.92+/-2.17 x 10(-6) s(-1) at ca. 25 degrees.

• Authors: Anthony J Di Pasqua, Silvia Wallner, Deborah J Kerwood, James C Dabrowiak
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 6 Issue 9 Pg. 1343-9 (Sep 2009) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 19774597 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• MCM-41
• Silicon Dioxide
• Carboplatin

Topics

• Adsorption
• Antineoplastic Agents (chemistry, pharmacology)
• Carboplatin (chemistry, pharmacology)
• Drug Carriers
• Magnetic Resonance Spectroscopy
• Silicon Dioxide (chemistry)
• Spectrophotometry, Ultraviolet