Abstract | PURPOSE: METHODS: Medical records from a prespecified 15-month period were retrospectively reviewed for all post-corneal transplant patients in whom loteprednol etabonate was initiated and prednisolone acetate 1.0% ophthalmic suspension withdrawn because of a secondary increase in IOP. Elevated postoperative IOP was defined as IOP that increased > or =21 mm Hg. Baseline IOP values were compared with IOP readings at follow-up examinations, with data points set retrospectively at 0-4, 4-8, 8-16, 16-32, and >32 weeks. Patient records were evaluated for any signs of allograft rejection during loteprednol etabonate therapy. RESULTS: Thirty patients were found to have switched to loteprednol etabonate after an increase in IOP during postoperative prednisolone acetate treatment. The mean reduction in IOP observed when comparing initial and final values in all 30 patients was 12.9 mm Hg during a mean follow-up of 21.6 weeks. The mean percent reduction in IOP during loteprednol etabonate treatment was 32.6% at 3 weeks and 44.9% at 39 weeks. No clinically observed signs of allograft rejection were documented. CONCLUSIONS:
|
Authors | Edward J Holland, Ali R Djalilian, Jeffrey P Sanderson |
Journal | Cornea
(Cornea)
Vol. 28
Issue 10
Pg. 1139-43
(Dec 2009)
ISSN: 1536-4798 [Electronic] United States |
PMID | 19770719
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Androstadienes
- Anti-Inflammatory Agents
- prednisolone acetate
- Prednisolone
- Loteprednol Etabonate
|
Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Androstadienes
(administration & dosage)
- Anti-Inflammatory Agents
(administration & dosage)
- Child
- Child, Preschool
- Corneal Transplantation
(adverse effects)
- Drug Administration Schedule
- Female
- Graft Rejection
(prevention & control)
- Humans
- Intraocular Pressure
(drug effects)
- Loteprednol Etabonate
- Male
- Middle Aged
- Ocular Hypertension
(drug therapy, etiology)
- Prednisolone
(administration & dosage, adverse effects, analogs & derivatives)
- Retrospective Studies
- Salvage Therapy
- Young Adult
|