Two novel ternary albendazole-cyclodextrin-polymer systems: dissolution, bioavailability and efficacy against Taenia crassiceps cysts.

Abstract

The effect of two water-soluble polymers: pectin and polyvinylpyrrolidone in combination with beta-cyclodextrin, on the dissolution, bioavailability and cysticidal efficacy of albendazole was evaluated using a commercial suspension as reference product. The dissolution of the albendazole-beta-cyclodextrin-pectin formulation was slow and incomplete (44.7%). No statistical differences in C(max) and AUC were found between this formulation and the reference. Also its cysticidal efficacy (33%) was similar to the reference (38%). The albendazole-beta-cyclodextrin-polyvinylpyrrolidone formulation exhibited the highest dissolution rate (78.5%) and its bioavailability was also significantly increased (2.3-fold). In addition, the cysticidal activity of this formulation (83%) was greater than a commercial suspension. Our results suggest that the ternary system of albendazole-beta-cyclodextrin-polyvinylpyrrolidone could be a potential alternative for the treatment of systemic helmintic diseases and it is worth to continue its preclinical evaluation.

• Authors: Francisca Palomares-Alonso, Cesar Rivas González, Ma Josefa Bernad-Bernad, María Dolores Castillo Montiel, Guadalupe Palencia Hernández, Iliana González-Hernández, Nelly Castro-Torres, Enrique Pinzón Estrada, Helgi Jung-Cook
• Journal: Acta tropica (Acta Trop) Vol. 113 Issue 1 Pg. 56-60 (Jan 2010) ISSN: 1873-6254 [Electronic] Netherlands
• PMID: 19769931 (Publication Type: Journal Article)

Chemical References

• Anticestodal Agents
• beta-Cyclodextrins
• Pectins
• Albendazole
• betadex

Topics

• Albendazole (chemistry, pharmacokinetics, pharmacology)
• Animals
• Anticestodal Agents (chemistry, pharmacokinetics, pharmacology)
• Male
• Mice
• Mice, Inbred BALB C
• Pectins (chemistry, pharmacokinetics, pharmacology)
• Rats
• Rats, Wistar
• Taenia (drug effects)
• beta-Cyclodextrins (chemistry, pharmacokinetics, pharmacology)