Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients.

Abstract

BACKGROUND:

The purpose of this study is to investigate the prognostic role of insulin-like growth factor receptor 1 (IGF1R) expression in surgically resected non-small-cell lung cancer (NSCLC). Patient characteristics and methods: This retrospective study was conducted in 369 stage I-II-IIIA, surgically resected, NSCLC patients. Patients exposed to anti-epidermal growth factor receptor (EGFR) agents were excluded. IGF1R expression was evaluated by immunohistochemistry in tissue microarray sections.

RESULTS:

A positive IGF1R expression (score > or = 100) was observed in 282 cases (76.4%) and was significantly associated with squamous cell histology (P = 0.04) and with grade III differentiation (P = 0.02). No difference in survival was observed between the positive and negative group when score 100 was used as cut-off for discriminating a positive versus a negative IGF1R result (52 versus 48 months, P = 0.99) or when median value of IGF1R expression was used (45 versus 55 months, P = 0.36). No difference in survival was observed between IGF1R-positive and -negative patients in a subgroup of stage I-II adenocarcinoma (n = 137) with known EGFR mutation and copy number status.

CONCLUSIONS:

IGF1R expression does not represent a prognostic factor in resected NSCLC patients. Patients with squamous cell carcinoma overexpress IGF1R more frequently than patients with nonsquamous histology, justifying the different sensitivity to anti-IGF1R agents observed in clinical trials.

• Authors: F Cappuzzo, G Tallini, G Finocchiaro, R S Wilson, C Ligorio, L Giordano, L Toschi, M Incarbone, R Cavina, L Terracciano, M Roncalli, M Alloisio, M Varella-Garcia, W A Franklin, A Santoro
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 21 Issue 3 Pg. 562-567 (Mar 2010) ISSN: 1569-8041 [Electronic] England
• PMID: 19767315 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptor, IGF Type 1

Topics

• Adenocarcinoma (metabolism, mortality, surgery)
• Adenocarcinoma, Bronchiolo-Alveolar (metabolism, mortality, surgery)
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Non-Small-Cell Lung (metabolism, mortality, surgery)
• Carcinoma, Squamous Cell (metabolism, mortality, surgery)
• Cohort Studies
• Female
• Humans
• Immunoenzyme Techniques
• Lung Neoplasms (metabolism, mortality, surgery)
• Male
• Middle Aged
• Neoplasm Staging
• Receptor, IGF Type 1 (metabolism)
• Retrospective Studies
• Survival Rate
• Tissue Array Analysis
• Treatment Outcome