Enhanced effect of neuropeptide Y on food intake caused by blockade of the V(1A) vasopressin receptor.

Abstract

Food intake is regulated by various factors such as neuropeptide Y. Neuropeptide Y potently induces an increase in food intake, and simultaneously stimulates arginine-vasopressin (AVP) secretion in the brain. Recently, we reported that V(1A) vasopressin receptor-deficient (V(1A)R(-/-)) mice exhibited altered daily food intake accompanied with hyperglycemia and hyperleptinemia. Here, we further study the involvement of the AVP/V(1A) receptor in the appetite regulation of neuropeptide Y with V(1A)R(-/-) mice and antagonists for the AVP receptor. The intra-cerebral-ventricle administration of neuropeptide Y induced greater food consumption in V(1A)R(-/-) mice than wild-type (WT) mice, whereas an anorexigenic effect of leptin was not different between the two groups. This finding suggests that the orexigenic effect of neuropeptide Y was enhanced in V(1A)R(-/-) mice, leading to the increased food intake in response to the neuropeptide Y stimulation. In addition, the neuropeptide Y-induced orexigenic effect was enhanced by co-administration of OPC-21268, an antagonist for the V(1A) vasopressin receptor, into the cerebral ventricle in WT mice, whereas the neuropeptide Y-induced orexigenic effect was not affected by co-administration of SSR-149415, an antagonist for the V(1B) vasopressin receptor. These results indicate that AVP could suppress the neuropeptide Y-induced orexigenic effect via the V(1A) vasopressin receptor, and that blockade or inhibition of the AVP/V(1A) receptor signal resulted in the enhanced neuropeptide Y-induced orexigenic effect. Thus, we show that the AVP/V(1A) receptor is involved in appetite regulation as an anorexigenic factor for the neuropeptide Y-induced orexigenic effect.

• Authors: Toshinori Aoyagi, Shinji Kusakawa, Atsushi Sanbe, Masami Hiroyama, Yoko Fujiwara, Junji Yamauchi, Akito Tanoue
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 622 Issue 1-3 Pg. 32-6 (Nov 10 2009) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 19766110 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidiuretic Hormone Receptor Antagonists
• Neuropeptide Y
• Receptors, Vasopressin
• Arginine Vasopressin

Topics

• Animals
• Antidiuretic Hormone Receptor Antagonists
• Appetite (drug effects)
• Arginine Vasopressin (metabolism, pharmacology)
• Eating (drug effects)
• Feeding Behavior (drug effects)
• Male
• Mice
• Mice, Inbred C57BL
• Neuropeptide Y (pharmacology)
• Receptors, Vasopressin (deficiency, metabolism)