Abstract | OBJECTIVE: The objective of this study was to investigate the efficacy of mesenchymal stem cell (MSC) in the treatment of arthritis. METHODS: RESULTS: Upon injection of MSCs, overall arthritis symptoms were significantly improved in the CIA mouse models as indicated by the paw edema. Consistent with this observation, serum levels of pro-inflammatory cytokine TNF-alpha and inflammatory cell infiltration decreased significantly 12 days after MSC injection, while the expression of anti-inflammatory cytokines IL-10, IP-10, and CXCR3 was increased in splenocytes. In addition, we provided evidence that MSCs may directly promote the proliferation of D2SC cells and the expression of IP-10 in D2SC cells in vitro. CONCLUSION:
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Authors | Fei Mao, Wen-Rong Xu, Hui Qian, Wei Zhu, Yong-Min Yan, Qi-Xiang Shao, Hua-Xi Xu |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 59
Issue 3
Pg. 219-25
(Mar 2010)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 19763787
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokine CXCL10
- Cytokines
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Topics |
- Animals
- Arthritis, Experimental
(metabolism, physiopathology, therapy)
- Cell Line
- Cell Proliferation
- Cell- and Tissue-Based Therapy
(methods)
- Chemokine CXCL10
(metabolism)
- Cytokines
(metabolism)
- Disease Models, Animal
- Male
- Mesenchymal Stem Cells
(physiology)
- Mice
- Mice, Inbred DBA
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