Abstract | BACKGROUND:
Fluoroquinolones are the drugs of choice for the treatment of typhoid fever. But the recent increase in minimum inhibitory concentration (MIC) values of ciprofloxacin in Salmonella Typhi may result in delayed response and serious complications. Nalidixic acid resistance has been used as an indirect evidence of increased minimum inhibitory concentration for ciprofloxacin in Salmonella Typhi. METHODS: We evaluated the isolates received at the National Salmonella and Escherichia Centre for nalidixic acid and ciprofloxacin susceptibility using standard methods. Minimum inhibitory concentrations have also been evaluated. RESULTS: CONCLUSION: The study may be helpful in revising treatment strategies for the infections caused by nalidixic acid resistant Salmonella Typhi in the country.
|
Authors | Yashwant Kumar, Anshu Sharma, Kavaratty Raju Mani |
Journal | Journal of infection in developing countries
(J Infect Dev Ctries)
Vol. 3
Issue 6
Pg. 467-9
(Jul 01 2009)
ISSN: 1972-2680 [Electronic] Italy |
PMID | 19762961
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Bacterial Agents
- Nalidixic Acid
- Ciprofloxacin
|
Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(pharmacology)
- Child
- Child, Preschool
- Ciprofloxacin
(pharmacology)
- Drug Resistance, Bacterial
- Female
- Humans
- India
- Male
- Microbial Sensitivity Tests
- Nalidixic Acid
(pharmacology)
- Salmonella typhi
(drug effects, isolation & purification)
- Typhoid Fever
(microbiology)
- Young Adult
|