Abstract | UNLABELLED: There is a high interest in developing an (18)F-labeled PET tracer that can aid in diagnosis and therapy monitoring of prostate cancer. In the current study, we have evaluated the potential of 2-(18)F-fluoropropionic acid ((18)F-FPA) as a PET tracer for imaging prostate cancer. METHODS:
(18)F-FPA was synthesized starting from methyl-2-bromopropionate. Small-animal PET studies were performed on mice with CWR22rv1, PC-3, DU-145, and LNCaP prostate xenografts, and comparison of imaging characteristics of (18)F-FPA with (18)F-FDG uptake is reported. Biodistribution studies with (18)F-FPA were performed on mice with CWR22rv1 xenografts and compared with (14)C-acetate. RESULTS:
(18)F-FPA was synthesized in 44% overall radiochemical yield (decay-corrected). Small-animal PET studies revealed that (18)F-FPA can delineate both androgen-dependent and androgen-independent prostate xenografts with high tumor-to-background ratios. Comparative imaging studies demonstrate the superior performance of (18)F-FPA over (18)F-FDG for imaging prostate cancer, with excellent tumor-to-background contrast. Biodistribution studies show that tumor uptake of the tracer was 5.52 +/- 0.35, 5.53 +/- 0.42, 5.74 +/- 0.54, and 5.34 +/- 0.19 percentage injected dose (%ID) per gram at 1, 2, 3, and 4 h, respectively, after injection. The %ID/g values for (18)F-FPA and (14)C-acetate 1 h after tail vein injection were 7.08 +/- 0.80 and 0.36 +/- 0.08 in tumor, and the corresponding tumor-to-muscle ratios were 1.94 and 2.06, respectively. CONCLUSION:
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Authors | Nagavarakishore Pillarsetty, Blesida Punzalan, Steven M Larson |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 50
Issue 10
Pg. 1709-14
(Oct 2009)
ISSN: 1535-5667 [Electronic] United States |
PMID | 19759108
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-18F-fluoropropionic acid
- Acetates
- Carbon Radioisotopes
- Fluorocarbons
- Octanols
- Propionates
- Radioactive Tracers
- Water
- propionic acid
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Topics |
- Acetates
(chemistry, pharmacokinetics)
- Animals
- Carbon Radioisotopes
(chemistry)
- Fluorocarbons
(chemistry, pharmacokinetics)
- Male
- Mice
- Octanols
(chemistry)
- Positron-Emission Tomography
(methods)
- Propionates
(chemistry, pharmacokinetics)
- Prostatic Neoplasms
(diagnostic imaging)
- Radioactive Tracers
- Tissue Distribution
- Water
(chemistry)
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