HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhaled budesonide for treatment of recurrent wheezing in early childhood.

Abstract
77 children, aged 11 to 36 months (mean 24) with moderately severe recurrent wheezing, were treated with budesonide pressurised aerosol 400 micrograms twice daily or placebo for 12 weeks in a double-blind, parallel-group trial. Aerosols were inhaled from a spacer with a facemask. Budesonide significantly improved symptom scores of wheezing, sleep disturbance, and patient happiness. The frequency of severe exacerbations that required a course of oral prednisolone was also significantly reduced. The treatment effect appeared to be fully established after 6-8 weeks and no side-effects could be ascribed to the active treatment. The findings indicate that young children below 3 years of age can inhale a pressurised aerosol from a spacer with a facemask. Use of topically active glucocorticosteroids with this simple device may reduce symptoms and distress in young children with moderately severe recurrent wheeze and dyspnoea, and possibly reduce their requirement for oral steroids.
AuthorsH Bisgaard, S L Munck, J P Nielsen, W Petersen, S V Ohlsson
JournalLancet (London, England) (Lancet) Vol. 336 Issue 8716 Pg. 649-51 (Sep 15 1990) ISSN: 0140-6736 [Print] England
PMID1975851 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Aerosols
  • Glucocorticoids
  • Pregnenediones
  • Budesonide
Topics
  • Administration, Inhalation
  • Administration, Oral
  • Aerosols
  • Budesonide
  • Child, Preschool
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Glucocorticoids (administration & dosage, therapeutic use)
  • Humans
  • Infant
  • Male
  • Masks
  • Multicenter Studies as Topic
  • Pregnenediones (administration & dosage, therapeutic use)
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Respiratory Sounds (drug effects)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: