Usefulness of suplatast tosilate for chronic cough following lung cancer surgery.

Abstract

OBJECTIVE:

Chronic dry cough is reported to occur in about 25% of patients following lung cancer surgery. Experimental data suggest that it may be caused mainly by stimulation of C-fibers, which are widely distributed to the lower trachea and bronchi. We assessed the clinical usefulness of suplatast tosilate (IPD) for chronic dry cough after lung cancer surgery.

METHODS:

The subjects were patients with stage I lung cancer who had undergone lobectomy combined with mediastinal lymph node dissection. IPD was administered orally at 400 mg daily, and its efficacy was evaluated by patient interview 1, 2, and 3 months after the start of treatment. The subjects were 19 patients, and the duration of cough before entering the study was 393.2 days.

RESULTS:

The response rate was 84.2% (16/19) 1 month after the start of treatment. It seems that IPD inhibits cough resulting from stimulation of the bifurcated trachea with a high content of C-fibers.

CONCLUSION:

The present study suggested the efficacy of IPD for controlling chronic dry cough after lung cancer surgery.

• Authors: Hideaki Miyamoto, Yukinori Sakao, Motoki Sakuraba, Shiaki Oh, Nobumasa Takahashi, Yoshikazu Miyasaka, Tomoya Inagaki, Taku Akaboshi, Enjo Hata
• Journal: General thoracic and cardiovascular surgery (Gen Thorac Cardiovasc Surg) Vol. 57 Issue 9 Pg. 463-6 (Sep 2009) ISSN: 1863-6713 [Electronic] Japan
• PMID: 19756932 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antitussive Agents
• Arylsulfonates
• Sulfonium Compounds
• suplatast tosilate

Topics

• Administration, Oral
• Aged
• Aged, 80 and over
• Antitussive Agents (administration & dosage, therapeutic use)
• Arylsulfonates (administration & dosage, therapeutic use)
• Chronic Disease
• Cough (drug therapy, etiology)
• Female
• Humans
• Lung Neoplasms (pathology, surgery)
• Lymph Node Excision
• Male
• Middle Aged
• Neoplasm Staging
• Pneumonectomy (adverse effects)
• Sulfonium Compounds (administration & dosage, therapeutic use)
• Time Factors
• Treatment Outcome