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Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.

Abstract
This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans blue leakage in mice. In addition, this compound exhibited significant systemic anti-inflammatory activity in carrageenan-induced mouse paw edema in a concentration-related manner (33.1-68.5% inhibition), and similar results were achieved in formalin test. Suppressive effects of cis-mulberroside A on the production of NO and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed. Collectively, cis-mulberroside A showed high analgesic and anti-inflammatory activities. The above results will be the supporting evidence for the potential anti-rheumatoid activity of R.mori in Chinese traditional medicine.
AuthorsZuofa Zhang, Liangen Shi
JournalFitoterapia (Fitoterapia) Vol. 81 Issue 3 Pg. 214-8 (Apr 2010) ISSN: 1873-6971 [Electronic] Netherlands
PMID19755140 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2009 Elsevier B.V. All rights reserved.
Chemical References
  • Analgesics
  • Anti-Inflammatory Agents
  • Disaccharides
  • Lipopolysaccharides
  • Plant Extracts
  • Stilbenes
  • mulberroside A
  • Formaldehyde
  • Nitric Oxide
  • Evans Blue
  • Carrageenan
  • Nitric Oxide Synthase Type II
  • Acetic Acid
Topics
  • Acetic Acid
  • Analgesics (isolation & purification, pharmacology, therapeutic use)
  • Animals
  • Anti-Inflammatory Agents (isolation & purification, pharmacology, therapeutic use)
  • Carrageenan
  • Cell Line
  • Disaccharides (isolation & purification, pharmacology, therapeutic use)
  • Dose-Response Relationship, Drug
  • Edema (chemically induced, drug therapy)
  • Evans Blue
  • Formaldehyde
  • Inflammation (drug therapy)
  • Lipopolysaccharides
  • Macrophages (drug effects)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Moraceae (chemistry)
  • Nitric Oxide (biosynthesis)
  • Nitric Oxide Synthase Type II (metabolism)
  • Pain (drug therapy)
  • Phytotherapy
  • Plant Extracts (chemistry, pharmacology, therapeutic use)
  • Plant Stems
  • Stilbenes (isolation & purification, pharmacology, therapeutic use)

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